|Other Accession||A1A4J7, NP_060619.4|
|Other Names||Protein SMG8, Amplified in breast cancer gene 2 protein, Protein smg-8 homolog, SMG8, ABC2, C17orf71|
|Target/Specificity||The synthetic peptide sequence is selected from aa 276-290 of HUMAN SMG8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.|
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Provided below are standard protocols that you may find useful for product applications.
Yamashita, A., et al. Genes Dev. 23(9):1091-1105(2009)
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