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ANKRD32 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9BQI6
Other Accession NP_115666.2
Additional Information
Gene ID 84250
Other Names Ankyrin repeat domain-containing protein 32, BRCT domain-containing protein 1, ANKRD32, BRCTD1
Target/Specificity The synthetic peptide sequence is selected from aa 174-188 of HUMAN ANKRD32
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLF1 {ECO:0000303|PubMed:25931565, ECO:0000312|HGNC:HGNC:25408}
Function Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
Cellular Location Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q8R3P9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R3P9}. Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage. Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5- SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin- dependent manner (PubMed:25931565). {ECO:0000250|UniProtKB:Q8R3P9, ECO:0000269|PubMed:25931565}
Research Areas
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References

Adams, D.J., et al. Mol. Cell. Biol. 25(2):779-788(2005)

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$ 80.00
$ 99.00
Cat# BP5407a
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