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TNFAIP1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13829 |
|---|---|
| Other Accession | O70479, NP_066960.1 |
| Gene ID | 7126 |
|---|---|
| Other Names | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, hBACURD2, BTB/POZ domain-containing protein TNFAIP1, Protein B12, Tumor necrosis factor, alpha-induced protein 1, endothelial, TNFAIP1, BACURD2, EDP1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 303-316 of HUMAN TNFAIP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TNFAIP1 |
|---|---|
| Synonyms | BACURD2, EDP1 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity. |
| Cellular Location | Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.
References
Grinchuk, O.V., et al. BMC Genomics 11 SUPPL 1, S9 (2010) :
Kim, D.M., et al. Int. J. Cancer 125(11):2520-2527(2009)
Castro-Giner, F., et al. Eur. Respir. J. 33(5):1003-1009(2009)
Yang, L.P., et al. Yi Chuan 28(8):918-922(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Suzuki, H., et al. Genome Res. 11(10):1758-1765(2001)
Pandey, A., et al. Science 268(5210):567-569(1995)
Wolf, F.W., et al. J. Biol. Chem. 267(2):1317-1326(1992)
Holzman, L.B., et al. Mol. Cell. Biol. 10(11):5830-5838(1990)
Dixit, V.M., et al. J. Biol. Chem. 265(5):2973-2978(1990)
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