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TNFAIP1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q13829
Other Accession O70479, NP_066960.1
Additional Information
Gene ID 7126
Other Names BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, hBACURD2, BTB/POZ domain-containing protein TNFAIP1, Protein B12, Tumor necrosis factor, alpha-induced protein 1, endothelial, TNFAIP1, BACURD2, EDP1
Target/Specificity The synthetic peptide sequence is selected from aa 303-316 of HUMAN TNFAIP1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFAIP1
Synonyms BACURD2, EDP1
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity.
Cellular Location Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes
Research Areas
Citations (0)
citation

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Background

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.

References

Grinchuk, O.V., et al. BMC Genomics 11 SUPPL 1, S9 (2010) :
Kim, D.M., et al. Int. J. Cancer 125(11):2520-2527(2009)
Castro-Giner, F., et al. Eur. Respir. J. 33(5):1003-1009(2009)
Yang, L.P., et al. Yi Chuan 28(8):918-922(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Suzuki, H., et al. Genome Res. 11(10):1758-1765(2001)
Pandey, A., et al. Science 268(5210):567-569(1995)
Wolf, F.W., et al. J. Biol. Chem. 267(2):1317-1326(1992)
Holzman, L.B., et al. Mol. Cell. Biol. 10(11):5830-5838(1990)
Dixit, V.M., et al. J. Biol. Chem. 265(5):2973-2978(1990)

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$ 277.78
Cat# BP5410b
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