|Other Names||Claudin-17, CLDN17|
|Target/Specificity||The synthetic peptide sequence is selected from aa 200-212 of HUMAN CLDN17|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi- pass membrane protein|
|Tissue Location||In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Hu, Y.H., et al. BMC Genomics 7, 155 (2006) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Katoh, M., et al. Int. J. Mol. Med. 11(6):683-689(2003)
Gonzalez-Mariscal, L., et al. Prog. Biophys. Mol. Biol. 81(1):1-44(2003)
Tsukita, S., et al. Curr. Opin. Cell Biol. 14(5):531-536(2002)
Brandner, J.M., et al. Eur. J. Cell Biol. 81(5):253-263(2002)
Tsukita, S., et al. Nat. Rev. Mol. Cell Biol. 2(4):285-293(2001)
Heiskala, M., et al. Traffic 2(2):93-98(2001)
Kniesel, U., et al. Cell. Mol. Neurobiol. 20(1):57-76(2000)
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