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DDHD1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8NEL9
Other Accession NP_085140.2, NP_001153620.1, NP_001153619.1
Additional Information
Gene ID 80821
Other Names Phospholipase DDHD1, 311-, DDHD domain-containing protein 1, Phosphatidic acid-preferring phospholipase A1 homolog, PA-PLA1, DDHD1, KIAA1705
Target/Specificity The synthetic peptide sequence is selected from aa 841-854 of HUMAN DDHD1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DDHD1 (HGNC:19714)
Synonyms KIAA1705
Function Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (PubMed:20359546, PubMed:22922100) (Probable). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2- diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2- diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (PubMed:20359546) (Probable). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962).
Cellular Location Cytoplasm.
Tissue Location Highly expressed in testis. Also expressed in brain, spleen and lung. Only expressed in cerebellum in fetal brain
Research Areas
Citations (0)
citation

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References

Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)
Houlston, R.S., et al. Nat. Genet. 40(12):1426-1435(2008)
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Higgs, H.N., et al. J. Biol. Chem. 273(10):5468-5477(1998)

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$ 277.78
Cat# BP5427b
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