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DHX58 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q96C10
Other Accession NP_077024.2
Additional Information
Gene ID 79132
Other Names Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2, Protein D11Lgp2 homolog, RIG-I-like receptor 3, RLR-3, RIG-I-like receptor LGP2, RLR, DHX58, D11LGP2E, LGP2
Target/Specificity The synthetic peptide sequence is selected from aa 56-69 of HUMAN DHX58
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHX58
Synonyms D11LGP2E, LGP2
Function Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Parisien, J.P., et al. J. Virol. 83(14):7252-7260(2009)
Li, X., et al. J. Biol. Chem. 284(20):13881-13891(2009)
Murali, A., et al. J. Biol. Chem. 283(23):15825-15833(2008)
Saito, T., et al. Proc. Natl. Acad. Sci. U.S.A. 104(2):582-587(2007)
Komuro, A., et al. J. Virol. 80(24):12332-12342(2006)
Yoneyama, M., et al. J. Immunol. 175(5):2851-2858(2005)
Cui, Y., et al. Genomics 78(3):129-134(2001)

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$ 80.00
$ 99.00
Cat# BP5429a
(40 western blots)
Availability: 2 weeks
Bulk Size
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