|Other Names||Exonuclease 3'-5' domain-containing protein 2, Exonuclease 3'-5' domain-like-containing protein 2, EXD2, C14orf114, EXDL2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 327-340 of HUMAN EXD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.|
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Provided below are standard protocols that you may find useful for product applications.
Barbe, L., et al. Mol. Cell Proteomics 7(3):499-508(2008)
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