TNPO3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5L0 |
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Other Accession | NP_036602 |
Clone Names | 81110060 |
Gene ID | 23534 |
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Other Names | Transportin-3, Importin-12, Imp12, Transportin-SR, TRN-SR, TNPO3, IPO12 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TNPO3 {ECO:0000303|PubMed:23667635, ECO:0000312|HGNC:HGNC:17103} |
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Function | Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914). |
Cellular Location | Nucleus envelope. Cytoplasm. Note=Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores |
Tissue Location | Expressed in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TNPO3 is a nuclear import receptor forserine/arginine-rich (SR) proteins, which are essentialprecursor-mRNA splicing factors.
References
Krishnan, L., et al. J. Virol. 84(1):397-406(2010)Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)Ito, I., et al. Arthritis Rheum. 60(6):1845-1850(2009)
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