|Other Names||Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface|
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The product of this gene belongs to the integrin alphachain family. Integrins are heterodimeric integral membraneproteins composed of an alpha chain and a beta chain. This geneencodes the integrin alpha 5 chain. Alpha chain 5 undergoespost-translational cleavage in the extracellular domain to yielddisulfide-linked light and heavy chains that join with beta 1 toform a fibronectin receptor. In addition to adhesion, integrins areknown to participate in cell-surface mediated signalling. [providedby RefSeq].
Kim, S., et al. Carcinogenesis 31(4):597-606(2010)Ryu, M.H., et al. Biochem. Biophys. Res. Commun. 393(1):11-15(2010)Yang, Y., et al. J. Biol. Chem. 285(1):131-141(2010)Lowin, T., et al. Arthritis Rheum. 60(12):3623-3632(2009)
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