CDKN2C Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P42773 |
---|---|
Other Accession | NP_523240 |
Clone Names | 81201086 |
Gene ID | 1031 |
---|---|
Other Names | Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CDKN2C |
---|---|
Synonyms | CDKN6 |
Function | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
Tissue Location | Highest levels found in skeletal muscle. Also found in pancreas and heart |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the INK4family of cyclin-dependent kinase inhibitors. This protein has beenshown to interact with CDK4 or CDK6, and prevent the activation ofthe CDK kinases, thus function as a cell growth regulator thatcontrols cell cycle G1 progression. Ectopic expression of this genewas shown to suppress the growth of human cells in a manner thatappears to correlate with the presence of a wild-type RB1 function.Studies in the knockout mice suggested the roles of this gene inregulating spermatogenesis, as well as in suppressingtumorigenesis. Two alternatively spliced transcript variants ofthis gene, which encode an identical protein, have been reported.
References
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Eguchi, T., et al. Mol. Cancer Ther. 8(6):1460-1472(2009)Pei, X.H., et al. Cancer Cell 15(5):389-401(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.