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PRPH Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P41219 |
|---|---|
| Other Accession | NP_006253.2 |
| Clone Names | 90415123 |
| Gene ID | 5630 |
|---|---|
| Other Names | Peripherin, Neurofilament 4, PRPH, NEF4, PRPH1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRPH |
|---|---|
| Synonyms | NEF4, PRPH1 |
| Function | Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15446584, PubMed:15322088). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, axon {ECO:0000250|UniProtKB:P15331}. Perikaryon {ECO:0000250|UniProtKB:P15331} |
| Tissue Location | Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytoskeletal protein found in neuronsof the peripheral nervous system. The encoded protein is a type IIIintermediate filament protein with homology to other cytoskeletalproteins such as desmin, and is a different protein that theperipherin found in photoreceptors.
References
McLenachan, S., et al. Transgenic Res. 17(6):1103-1116(2008)Willoughby, V., et al. Appl. Immunohistochem. Mol. Morphol. 16(4):344-348(2008)Sunesson, L., et al. J. Biol. Chem. 283(24):16653-16664(2008)Djabali, K., et al. Cell 64(1):109-121(1991)
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