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EHMT2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96KQ7 |
|---|---|
| Other Accession | NP_006700.3 |
| Clone Names | 90429118 |
| Gene ID | 10919 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase EHMT2, 211-, Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Lysine N-methyltransferase 1C, Protein G9a, EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EHMT2 |
|---|---|
| Synonyms | BAT8, C6orf30, G9A, KMT1C, NG36 |
| Function | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Recruited to the promoters of target genes through interaction with transcriptional repressor MSX1, leading to the inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity). |
| Cellular Location | Nucleus. Chromosome. Note=Associates with euchromatic regions (PubMed:11316813). Does not associate with heterochromatin (PubMed:11316813). |
| Tissue Location | Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow |
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Provided below are standard protocols that you may find useful for product applications.
Background
A cluster of genes, BAT1-BAT5, has been localized in thevicinity of the genes for TNF alpha and TNF beta. This gene isfound near this cluster; it was mapped near the gene for C2 withina 120-kb region that included a HSP70 gene pair. These genes areall within the human major histocompatibility complex class IIIregion. This gene was thought to be two different genes, NG36 andG9a, adjacent to each other but a recent publication shows thatthere is only a single gene. The protein encoded by this gene isthought to be involved in intracellular protein-proteininteraction.
References
Goyama, S., et al. Leukemia 24(1):81-88(2010)de Vogel, S., et al. Cancer Epidemiol. Biomarkers Prev. 18(11):3086-3096(2009)Chen, X., et al. J. Biol. Chem. 284(41):27857-27865(2009)
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