|Other Names||Pro-MCH, Neuropeptide-glycine-glutamic acid, NGE, Neuropeptide G-E, Neuropeptide-glutamic acid-isoleucine, NEI, Neuropeptide E-I, Melanin-concentrating hormone, MCH, PMCH, MCH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.|
|Tissue Location||Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly.|
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The melanin-concentrating hormone (MCH) is a cyclicneuropeptide isolated initially from salmon pituitary gland andlater from rat hypothalamus (summarized by Nahon et al., 1992[PubMed 1572663]). In mammals, MCH perikarya are confined largelyto the lateral hypothalamus and zona incerta area with extensiveneuronal projections throughout the brain, including theneurohypophysis. The anatomic distribution suggests aneurotransmitter or neuromodulator role for MCH in a broad array ofneuronal functions directed toward the regulation of goal-directedbehavior, such as food intake, and general arousal. MCH and 2 otherputative neuropeptides, NEI and NGE, are encoded by the sameprecursor and appear colocalized in nerve cells and in manyinstances within the projections. The precursor is designatedpro-melanin-concentrating hormone (PMCH).
Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Aziz, A., et al. Brain Pathol. 18(4):474-483(2008)Kokkotou, E., et al. Proc. Natl. Acad. Sci. U.S.A. 105(30):10613-10618(2008)
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