RPS3A Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P61247 |
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Other Accession | NP_000997.1 |
Clone Names | 90625200 |
Gene ID | 6189 |
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Other Names | 40S ribosomal protein S3a {ECO:0000255|HAMAP-Rule:MF_03122}, v-fos transformation effector protein, Fte-1, RPS3A {ECO:0000255|HAMAP-Rule:MF_03122}, FTE1, MFTL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RPS3A {ECO:0000255|HAMAP-Rule:MF_03122} |
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Synonyms | FTE1, MFTL |
Function | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:23636399}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03122}. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs |
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Background
Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 40S subunit. The protein belongsto the S3AE family of ribosomal proteins. It is located in thecytoplasm. Disruption of the gene encoding rat ribosomal proteinS3a, also named v-fos transformation effector protein, inv-fos-transformed rat cells results in reversion of the transformedphenotype. Transcript variants utilizing alternative transcriptionstart sites have been described. This gene is co-transcribed withthe U73A and U73B small nucleolar RNA genes, which are located inits fourth and third introns, respectively. As is typical for genesencoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome.
References
Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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