|Other Names||Glutamate receptor ionotropic, NMDA 1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, GRIN1, NMDAR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This protein is a critical subunit ofN-methyl-D-aspartate receptors, members of the glutamate receptorchannel superfamily which are heteromeric protein complexes withmultiple subunits arranged to form a ligand-gated ion channel.These subunits play a key role in the plasticity of synapses, whichis believed to underlie memory and learning. Cell-specific factorsare thought to control expression of different isoforms, possiblycontributing to the functional diversity of the subunits.Alternatively spliced transcript variants have been described.
Davila, S., et al. Genes Immun. (2010) In press :McNearney, T.A., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 (3), R584-R598 (2010) :Gong, Y., et al. Brain Res. 1292, 191-198 (2009) :Bodarky, C.L., et al. J. Pharmacol. Exp. Ther. 331(1):308-318(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.