|Other Names||Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2, Centrosome-associated protein, BLOC1S2, BLOS2, CEAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end- directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Lysosome membrane. Note=Localizes to the centrosomes in a microtubule-dependent manner|
|Tissue Location||Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
BLOC1S2 is a component of the ubiquitously expressed BLOC1multisubunit protein complex. BLOC1 is required for normalbiogenesis of specialized organelles of the endosomal-lysosomalsystem, such as melanosomes and platelet dense granules (Starcevicand Dell'Angelica, 2004 [PubMed 15102850]).
Rodriguez-Fernandez, I.A., et al. J. Inherit. Metab. Dis. 32(2):190-203(2009)Gdynia, G., et al. Apoptosis 13(3):437-447(2008)Wang, Z., et al. J. Mol. Biol. 343(1):71-82(2004)
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