|Other Names||Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Melanocytes and corticoadrenal tissue.|
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Provided below are standard protocols that you may find useful for product applications.
MC2R encodes one member of the five-member G-proteinassociated melanocortin receptor family. Melanocortins(melanocyte-stimulating hormones and adrenocorticotropic hormone)are peptides derived from pro-opiomelanocortin (POMC). MC2R isselectively activated by adrenocorticotropic hormone, whereas theother four melanocortin receptors recognize a variety ofmelanocortin ligands.
Holliday, K.L., et al. Ann. Rheum. Dis. 69(3):556-560(2010)Ding, Y.X., et al. Pharmacogenet. Genomics 20(2):71-76(2010)Roy, S., et al. Endocrinology 151(2):660-670(2010)
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