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MC2R Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q01718 |
|---|---|
| Other Accession | NP_000520.1 |
| Clone Names | 90723080 |
| Gene ID | 4158 |
|---|---|
| Other Names | Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MC2R |
|---|---|
| Synonyms | ACTHR |
| Function | Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Melanocytes and corticoadrenal tissue. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MC2R encodes one member of the five-member G-proteinassociated melanocortin receptor family. Melanocortins(melanocyte-stimulating hormones and adrenocorticotropic hormone)are peptides derived from pro-opiomelanocortin (POMC). MC2R isselectively activated by adrenocorticotropic hormone, whereas theother four melanocortin receptors recognize a variety ofmelanocortin ligands.
References
Holliday, K.L., et al. Ann. Rheum. Dis. 69(3):556-560(2010)Ding, Y.X., et al. Pharmacogenet. Genomics 20(2):71-76(2010)Roy, S., et al. Endocrinology 151(2):660-670(2010)
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