|Other Names||Homeobox protein EMX2, Empty spiracles homolog 2, Empty spiracles-like protein 2, EMX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.|
|Tissue Location||Cerebral cortex.|
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This gene encodes a homeobox-containing transcriptionfactor that is the homolog to the 'empty spiracles' gene inDrosophila. Research on this gene in humans has focused on itsexpression in three tissues: dorsal telencephalon, olfactoryneuroepithelium, and urogenetial system. It is expressed in thedorsal telencephalon during development in a low rostral-lateral tohigh caudal-medial gradient and is proposed to pattern theneocortex into defined functional areas. It is also expressed inembryonic and adult olfactory neuroepithelia where it complexeswith eukaryotic translation initiation factor 4E (eIF4E) andpossibly regulates mRNA transport or translation. In the developingurogenital system, it is expressed in epithelial tissues and isnegatively regulated by HOXA10. Alternative splicing results inmultiple transcript variants encoding distinct proteins.
Inkster, B., et al. Neuroimage (2010) In press :Bayatti, N., et al. Eur. J. Neurosci. 28(8):1449-1456(2008)Merello, E., et al. Am. J. Med. Genet. A 146A (9), 1142-1150 (2008) :Treloar, S.A., et al. Mol. Hum. Reprod. 13(8):587-594(2007)
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