|Other Names||Colipase, CLPS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|
|Tissue Location||Expressed by the pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cofactor needed bypancreatic lipase for efficient dietary lipid hydrolysis. It bindsto the C-terminal, non-catalytic domain of lipase, therebystabilizing an active conformation and considerably increasing theoverall hydrophobic binding site. The gene product allows lipase toanchor noncovalently to the surface of lipid micelles,counteracting the destabilizing influence of intestinal bile salts.This cofactor is only expressed in pancreatic acinar cells,suggesting regulation of expression by tissue-specific elements.
Weyrich, P., et al. Exp. Clin. Endocrinol. Diabetes 117(2):83-87(2009)Wermter, A.K., et al. Obes Facts 2(1):40-44(2009)D'Silva, S., et al. J. Lipid Res. 48(11):2478-2484(2007)Lindner, I., et al. Mol Nutr Food Res 49(10):972-976(2005)
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