|Other Names||Putative killer cell immunoglobulin-like receptor like protein KIR3DP1, CD158c, KIR3DP1, CD158C, KIR2DS6, KIR48, KIRX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD158C, KIR2DS6, KIR48, KIRX|
|Tissue Location||Expressed in peripheral blood cells.|
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Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response. This gene is one of the'framework' loci that is present on all haplotypes. This locusrepresents an alternate copy of KIR3DP1 that is represented in asmall percentage of the population and may encode a functionalprotein. The other copy is considered to be a pseudogene. [providedby RefSeq].
Levinson, R.D., et al. Hum. Immunol. 69(6):349-353(2008)Dou, L.P., et al. Int. J. Hematol. 87(4):422-433(2008)Pavlova, Y., et al. Int. J. Immunogenet. 35(1):57-61(2008)Gomez-Lozano, N., et al. Eur. J. Immunol. 35(1):16-24(2005)Martin, A.M., et al. Gene 335, 121-131 (2004) :
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