|Other Names||Calmodulin-like protein 5, Calmodulin-like skin protein, CALML5, CLSP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds calcium. May be involved in terminal differentiation of keratinocytes.|
|Tissue Location||Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung|
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This gene encodes a novel calcium binding proteinexpressed in the epidermis and related to the calmodulin family ofcalcium binding proteins. Functional studies with recombinantprotein demonstrate it does bind calcium and undergoes aconformational change when it does so. Abundant expression isdetected only in reconstructed epidermis and is restricted todifferentiating keratinocytes. In addition, it can associate withtransglutaminase 3, shown to be a key enzyme in the terminaldifferentiation of keratinocytes.
Durussel, I., et al. Biochemistry 41(17):5439-5448(2002)Mehul, B., et al. J. Invest. Dermatol. 116(6):905-909(2001)Mehul, B., et al. J. Biol. Chem. 275(17):12841-12847(2000)
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