|Other Names||Paraspeckle component 1, Paraspeckle protein 1, PSPC1, PSP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles.|
|Cellular Location||Nucleus, nucleolus. Nucleus matrix. Cytoplasm. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps|
|Tissue Location||Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart|
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Provided below are standard protocols that you may find useful for product applications.
PSPC1 rfegulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity) and binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity).
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Fox, A.H., et al. Mol. Biol. Cell 16(11):5304-5315(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Fox, A.H., et al. Curr. Biol. 12(1):13-25(2002)
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