|Other Names||Metalloreductase STEAP2, 1161-, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, STEAP2, PCANAP1, STAMP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.|
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This gene is a member of the STEAP family and encodes amulti-pass membrane protein that localizes to the Golgi complex,the plasma membrane, and the vesicular tubular structures in thecytosol. A highly similar protein in mouse has both ferrireductaseand cupric reductase activity, and stimulates the cellular uptakeof both iron and copper in vitro. Increased transcriptionalexpression of the human gene is associated with prostate cancerprogression. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized.
Vaghjiani, R.J., et al. Tissue Eng Part A 15(8):2073-2083(2009)Denoeud, F., et al. Genome Res. 17(6):746-759(2007)Ohgami, R.S., et al. Blood 108(4):1388-1394(2006)
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