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SIA7C Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NDV1 |
|---|---|
| Other Accession | NP_694541.1 |
| Clone Names | 91109215 |
| Gene ID | 256435 |
|---|---|
| Other Names | Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 3, 2499-, GalNAc alpha-2, 6-sialyltransferase III, ST6GalNAc III, ST6GalNAcIII, STY, Sialyltransferase 7C, SIAT7-C, ST6GALNAC3, SIAT7C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ST6GALNAC3 |
|---|---|
| Synonyms | SIAT7C |
| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
| Tissue Location | Expressed in brain and kidney (PubMed:16169874, PubMed:17123352). Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules (PubMed:17123352). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ST6GALNAC3 belongs to a family of sialyltransferases thattransfer sialic acids from CMP-sialic acid to terminal positions ofcarbohydrate groups in glycoproteins and glycolipids.
References
Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)Senda, M., et al. Biochem. J. 402(3):459-470(2007)Tsuchida, A., et al. J. Biochem. 138(3):237-243(2005)Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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