|Other Names||TATA box-binding protein-associated factor RNA polymerase I subunit D, RNA polymerase I-specific TBP-associated factor 41 kDa, TAFI41, TATA box-binding protein-associated factor 1D, TBP-associated factor 1D, Transcription initiation factor SL1/TIF-IB subunit D, TAF1D, JOSD3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|
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Provided below are standard protocols that you may find useful for product applications.
TAF1D is a member of the SL1 complex, which includes TBP(MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C(MIM 604905), and plays a role in RNA polymerase I transcription(Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed17318177]).
Gorski, J.J., et al. EMBO J. 26(6):1560-1568(2007)Wang, L., et al. Cancer Res. 64(21):7673-7677(2004)
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