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TNIP3 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96KP6
Other Accession NP_001122315.1, NP_079149.3
Clone Names 91119281
Peptide ID 91119281
Additional Information
Gene ID 79931
Other Names TNFAIP3-interacting protein 3, A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, Listeria-induced gene protein, TNIP3 (HGNC:19315), ABIN3, LIND
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNIP3 (HGNC:19315)
Synonyms ABIN3, LIND
Function Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Tissue Location Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.
Research Areas
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Background

TNIP3 binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. It Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

References

Folco, E.J., et al. J. Biol. Chem. 284(38):25569-25575(2009)Verstrepen, L., et al. Biochem. Pharmacol. 78(2):105-114(2009)Wullaert, A., et al. J. Biol. Chem. 282(1):81-90(2007)Staege, H., et al. Immunogenetics 53(2):105-113(2001)

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$ 80.00
Cat# BP5598a
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