|Other Names||Zinc finger protein 90 homolog, Zfp-90, Zinc finger protein 756, ZFP90, KIAA1954, ZNF756|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity). Isoform 2 acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg) (PubMed:23543754).|
|Tissue Location||Isoform 2 is highly expressed in the regulatory T-cells (Treg).|
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Provided below are standard protocols that you may find useful for product applications.
ZFP90 may function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc dependent binding to DNA. It may be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state.
Barrett, J.C., et al. Nat. Genet. 41(12):1330-1334(2009)Macedo-Souza, L.I., et al. Ann. Neurol. 57(5):730-737(2005)Lange, R., et al. DNA Cell Biol. 14(11):971-981(1995)
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