|Other Names||Spermatid-specific manchette-related protein 1, Ciliated bronchial epithelial protein 1, Testis development protein NYD-SP22, SMRP1, C9orf24, CBE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells.|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Note=Localizes to the manchette in elongating spermatids (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines|
|Tissue Location||Expressed in epithelial cells of nasal polyps and in intact epithelium of bronchial biopsies from subjects with and without asthma. Strong expression in columnar cells with little or no expression in basal epithelial cells along the basement membrane. Strongly expressed in ciliated epithelial cells with lower levels in goblet cells (at protein level)|
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This gene was isolated using microarray hybridization toscreen for gene expression differences between fetal and adulttestes. The conserved testis development-related genes found inboth human and mouse testes may include genes that are likely to beinvolved in testicular functions, including spermatogenesis. Thisgene had higher expression in adults, compared to 6-month embryos.The specific function of this gene product has not been determined.Alternative splicing has been observed at this locus and threetranscript variants, each encoding a distinct isoform, have beenidentified.
Haitchi, H.M., et al. Eur. Respir. J. 33(5):1095-1104(2009)Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005) :Yoshisue, H., et al. Am. J. Respir. Cell Mol. Biol. 31(5):491-500(2004)Sha, J., et al. Mol. Hum. Reprod. 8(6):511-517(2002)
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