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CI024 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NCR6 |
|---|---|
| Other Accession | NP_115985.2 |
| Clone Names | 91119304 |
| Gene ID | 84688 |
|---|---|
| Other Names | Spermatid-specific manchette-related protein 1, Ciliated bronchial epithelial protein 1, Testis development protein NYD-SP22, SMRP1, C9orf24, CBE1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SPMIP6 (HGNC:19919) |
|---|---|
| Function | May participate in intramanchette transport and midpiece formation of the sperm tail. May play a potential role in somatic cell proliferation. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2MH31}. Nucleus Cytoplasm. Mitochondrion {ECO:0000250|UniProtKB:Q2MH31}. Cell projection, cilium, flagellum. Note=During spermatid elongation (step 10), localizes along the length of the manchette and later during the elongation process only at the distal ends of spermatid manchette (step 12). In late elongated spermatids (step 16), in the final steps of spermiogenesis, localization is restricted to the midpiece of the flagellum. Localizes at the contractile ring in dividing cells (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines (PubMed:15242845) {ECO:0000250|UniProtKB:Q2MH31, ECO:0000269|PubMed:15242845} |
| Tissue Location | Expressed in testis (PubMed:28601408). Strongly expressed in ciliated epithelial cells with lower levels in goblet cells (at protein level) (PubMed:15242845) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was isolated using microarray hybridization toscreen for gene expression differences between fetal and adulttestes. The conserved testis development-related genes found inboth human and mouse testes may include genes that are likely to beinvolved in testicular functions, including spermatogenesis. Thisgene had higher expression in adults, compared to 6-month embryos.The specific function of this gene product has not been determined.Alternative splicing has been observed at this locus and threetranscript variants, each encoding a distinct isoform, have beenidentified.
References
Haitchi, H.M., et al. Eur. Respir. J. 33(5):1095-1104(2009)Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005) :Yoshisue, H., et al. Am. J. Respir. Cell Mol. Biol. 31(5):491-500(2004)Sha, J., et al. Mol. Hum. Reprod. 8(6):511-517(2002)
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