|Other Names||Lysophospholipid acyltransferase 1, LPLAT 1, 231-, 1-acylglycerophosphoserine O-acyltransferase, 231n6, Lysophosphatidylserine acyltransferase, LPSAT, Lyso-PS acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 1, O-acyltransferase domain-containing protein 1, MBOAT1, OACT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in neutrophils.|
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Provided below are standard protocols that you may find useful for product applications.
MBOAT1 shares structural similarity with a superfamily ofmembrane-bound O-acetyltransferases that transfer organiccompounds, usually fatty acids (e.g., cholesterol, diacylglycerol,palmitoyl), onto hydroxyl groups of membrane-embedded targets(Dauwerse et al., 2007 [PubMed 17440500]).
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Hishikawa, D., et al. Proc. Natl. Acad. Sci. U.S.A. 105(8):2830-2835(2008)Tamaki, H., et al. J. Biol. Chem. 282(47):34288-34298(2007)Dauwerse, J.G., et al. Eur. J. Hum. Genet. 15(7):743-751(2007)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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