|Other Names||Cerebellin-3, CBLN3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in synaptic functions in the CNS.|
|Cellular Location||Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Cell junction, synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on a association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Members of the precerebellin family, such as CBLN3,contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminalC1q signature domain (see MIM 120550) that mediates trimericassembly of atypical collagen complexes. However, precerebellins donot contain a collagen motif, suggesting that they are notconventional components of the extracellular matrix (Pang et al.,2000 [PubMed 10964938]).
Bao, D., et al. Mol. Cell. Biol. 26(24):9327-9337(2006)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Pang, Z., et al. J. Neurosci. 20(17):6333-6339(2000)
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