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GANAB Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14697
Other Accession NP_938148.1
Clone Names 91009169
Peptide ID 91009169
Additional Information
Gene ID 23193
Other Names Neutral alpha-glucosidase AB, Alpha-glucosidase 2, Glucosidase II subunit alpha, GANAB, G2AN, KIAA0088
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GANAB
Synonyms G2AN, KIAA0088
Function Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053).
Cellular Location Endoplasmic reticulum. Golgi apparatus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Tissue Location Detected in placenta (PubMed:3881423). Isoform 1 and isoform 2 are expressed in the kidney and liver (PubMed:27259053).
Research Areas
Citations (0)

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Background

Glucosidase II is an endoplasmic reticulum localized enzyme that has an important function in the folding and maturation of glycoproteins. Glucosidase II is composed of two soluble proteins: a catalytic alpha-subunit and a beta-subunit of unknown function, both of which are highly conserved in mammals.

References

Arendt, C.W., et al. Glycobiology 10(5):487-492(2000)Arendt, C.W., et al. J. Biol. Chem. 272(20):13117-13125(1997)Trombetta, E.S., et al. J. Biol. Chem. 271(44):27509-27516(1996)Martiniuk, F., et al. J. Biol. Chem. 260(2):1238-1242(1985)Martiniuk, F., et al. Cytogenet. Cell Genet. 35(2):110-116(1983)

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$ 80.00
Cat# BP5653a
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