|Other Names||Neutral alpha-glucosidase AB, Alpha-glucosidase 2, Glucosidase II subunit alpha, GANAB, G2AN, KIAA0088|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053).|
|Cellular Location||Endoplasmic reticulum. Golgi apparatus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Detected in placenta (PubMed:3881423). Isoform 1 and isoform 2 are expressed in the kidney and liver (PubMed:27259053).|
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Provided below are standard protocols that you may find useful for product applications.
Glucosidase II is an endoplasmic reticulum localized enzyme that has an important function in the folding and maturation of glycoproteins. Glucosidase II is composed of two soluble proteins: a catalytic alpha-subunit and a beta-subunit of unknown function, both of which are highly conserved in mammals.
Arendt, C.W., et al. Glycobiology 10(5):487-492(2000)Arendt, C.W., et al. J. Biol. Chem. 272(20):13117-13125(1997)Trombetta, E.S., et al. J. Biol. Chem. 271(44):27509-27516(1996)Martiniuk, F., et al. J. Biol. Chem. 260(2):1238-1242(1985)Martiniuk, F., et al. Cytogenet. Cell Genet. 35(2):110-116(1983)
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