|Other Names||Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Ikaros family ofzinc-finger proteins. Three members of this protein family (Ikaros,Aiolos and Helios) are hematopoietic-specific transcription factorsinvolved in the regulation of lymphocyte development. This geneproduct is a transcription factor that is important in theregulation of B lymphocyte proliferation and differentiation. BothIkaros and Aiolos can participate in chromatin remodeling.Regulation of gene expression in B lymphocytes by Aiolos is complexas it appears to require the sequential formation of Ikaroshomodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Atleast six alternative transcripts encoding different isoforms havebeen described.
Billot, K., et al. Leuk. Res. 34(3):289-293(2010)Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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