|Other Names||Cathepsin G, CG, CTSG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride.|
|Cellular Location||Cell surface.|
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Provided below are standard protocols that you may find useful for product applications.
CTSG, a member of thepeptidase S1 protein family, is found in azurophil granules ofneutrophilic polymorphonuclear leukocytes. The encoded protease hasa specificity similar to that of chymotrypsin C, and mayparticipate in the killing and digestion of engulfed pathogens, andin connective tissue remodeling at sites of inflammation.Transcript variants utilizing alternative polyadenylation signalsexist for this gene.
Burster, T., et al. Mol. Immunol. 47(4):658-665(2010)Standish, A.J., et al. J. Immunol. 183(4):2602-2609(2009)Yoshida, T., et al. Int. J. Mol. Med. 24(2):233-246(2009)Ribatti, D., et al. Cancer Lett. 279(2):209-212(2009)
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