GZMK Antibody (Center K94) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49863 |
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Other Accession | NP_002095 |
Clone Names | 80513183 |
Gene ID | 3003 |
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Other Names | Granzyme K, 3421-, Fragmentin-3, Granzyme-3, NK-tryptase-2, NK-Tryp-2, GZMK, TRYP2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GZMK |
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Synonyms | TRYP2 |
Cellular Location | Secreted. Cytoplasmic granule. |
Tissue Location | Expressed in lung, spleen, thymus and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
GZMK is a member of a group of related serineproteases from the cytoplasmic granules of cytotoxic lymphocytes.Cytolytic T lymphocytes (CTL) and natural killer (NK) cells sharethe remarkable ability to recognize, bind, and lyse specific targetcells. They are thought to protect their host by lysing cellsbearing on their surface 'nonself' antigens, usually peptides orproteins resulting from infection by intracellular pathogens. Theprotein described here lacks consensus sequences forN-glycosylation present in other granzymes.
References
Baker, E., et al. Immunogenetics 40(3):235-237(1994)Shi, L., et al. J. Exp. Med. 176(6):1521-1529(1992)Hameed, A., et al. J. Immunol. 141(9):3142-3147(1988)
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