|Other Names||Granzyme K, 3421-, Fragmentin-3, Granzyme-3, NK-tryptase-2, NK-Tryp-2, GZMK, TRYP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Secreted. Cytoplasmic granule.|
|Tissue Location||Expressed in lung, spleen, thymus and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
GZMK is a member of a group of related serineproteases from the cytoplasmic granules of cytotoxic lymphocytes.Cytolytic T lymphocytes (CTL) and natural killer (NK) cells sharethe remarkable ability to recognize, bind, and lyse specific targetcells. They are thought to protect their host by lysing cellsbearing on their surface 'nonself' antigens, usually peptides orproteins resulting from infection by intracellular pathogens. Theprotein described here lacks consensus sequences forN-glycosylation present in other granzymes.
Baker, E., et al. Immunogenetics 40(3):235-237(1994)Shi, L., et al. J. Exp. Med. 176(6):1521-1529(1992)Hameed, A., et al. J. Immunol. 141(9):3142-3147(1988)
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