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NAT1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18440 |
|---|---|
| Other Accession | NP_000653.3 |
| Clone Names | 90625128 |
| Gene ID | 9 |
|---|---|
| Other Names | Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1, NAT1, AAC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NAT1 |
|---|---|
| Synonyms | AAC1 |
| Function | Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Nat1 is one of two arylamine N-acetyltransferase(NAT) genes in the human geneome, and is orthologous to the mouseand rat Nat2 genes. The enzyme encoded by this gene catalyzes thetransfer of an acetyl group from acetyl-CoA to various arylamineand hydrazine substrates. This enzyme helps metabolize drugs andother xenobiotics, and functions in folate catabolism.
References
Butcher, N.J., et al. J. Biol. Chem. 279(21):22131-22137(2004)Butcher, N.J., et al. Biochem. J. 376 (PT 2), 441-448 (2003) Dupret, J.M., et al. J. Biol. Chem. 267(11):7381-7385(1992)
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