|Other Names||Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1, NAT1, AAC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.|
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Provided below are standard protocols that you may find useful for product applications.
Nat1 is one of two arylamine N-acetyltransferase(NAT) genes in the human geneome, and is orthologous to the mouseand rat Nat2 genes. The enzyme encoded by this gene catalyzes thetransfer of an acetyl group from acetyl-CoA to various arylamineand hydrazine substrates. This enzyme helps metabolize drugs andother xenobiotics, and functions in folate catabolism.
Butcher, N.J., et al. J. Biol. Chem. 279(21):22131-22137(2004)Butcher, N.J., et al. Biochem. J. 376 (PT 2), 441-448 (2003) Dupret, J.M., et al. J. Biol. Chem. 267(11):7381-7385(1992)
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