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IFIH1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BYX4
Other Accession NP_071451.2
Clone Names 90713087
Peptide ID 90713087
Additional Information
Gene ID 64135
Other Names Interferon-induced helicase C domain-containing protein 1, Clinically amyopathic dermatomyositis autoantigen 140 kDa, CADM-140 autoantigen, Helicase with 2 CARD domains, Helicard, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, Murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2, RNA helicase-DEAD box protein 116, IFIH1, MDA5, RH116
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFIH1
Synonyms MDA5, RH116
Function Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
Cellular Location Cytoplasm. Nucleus. Note=May be found in the nucleus, during apoptosis
Tissue Location Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung
Research Areas
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DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this familyare believed to be involved in embryogenesis, spermatogenesis, andcellular growth and division. This gene encodes a DEAD box proteinthat is upregulated in response to treatment with beta-interferon(IFNB) and a protein kinase C-activating compound, mezerein (MEZ).Irreversible reprogramming of melanomas can be achieved bytreatment with both these agents; treatment with either agent aloneonly achieves reversible differentiation.


Andrejeva, J., et al. Proc. Natl. Acad. Sci. U.S.A. 101(49):17264-17269(2004)Kang, D.C., et al. Oncogene 23(9):1789-1800(2004)Cocude, C., et al. J. Gen. Virol. 84 (PT 12), 3215-3225 (2003) Kovacsovics, M., et al. Curr. Biol. 12(10):838-843(2002)Kang, D.C., et al. Proc. Natl. Acad. Sci. U.S.A. 99(2):637-642(2002)

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$ 80.00
Cat# BP5679a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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