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ERCC4 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92889 |
|---|---|
| Other Accession | NP_005227.1 |
| Clone Names | 90415044 |
| Gene ID | 2072 |
|---|---|
| Other Names | DNA repair endonuclease XPF, 31--, DNA excision repair protein ERCC-4, DNA repair protein complementing XP-F cells, Xeroderma pigmentosum group F-complementing protein, ERCC4, ERCC11, XPF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ERCC4 {ECO:0000303|PubMed:8887684, ECO:0000312|HGNC:HGNC:3436} |
|---|---|
| Function | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. |
| Cellular Location | Nucleus. Chromosome. Note=Localizes to sites of DNA damage |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene forms a complex withERCC1 and is involved in the 5' incision made during nucleotideexcision repair. This complex is a structure specific DNA repairendonuclease that interacts with EME1. Defects in this gene are acause of xeroderma pigmentosum complementation group F (XP-F), orxeroderma pigmentosum VI (XP6).
References
Sijbers, A.M., et al. Cell 86(5):811-822(1996)Park, C.H., et al. J. Biol. Chem. 270(39):22657-22660(1995)Park, C.H., et al. Proc. Natl. Acad. Sci. U.S.A. 91(11):5017-5021(1994)Liu, P., et al. Mutagenesis 8(3):199-205(1993)
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