|Other Names||Protein Wnt-5a, WNT5A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable Expression is found in thyrocytes but not in stromal cells (at protein level).|
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The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98%, 98% and 87% amino acid identityto the mouse, rat and the xenopus Wnt5A protein, respectively. Theexperiments performed in Xenopus laevis embryos identified thathuman frizzled-5 (hFz5) is the receptor for the Wnt5A ligand andthe Wnt5A/hFz5 signaling mediates axis induction. [provided byRefSeq].
He, X., et al. Science 275(5306):1652-1654(1997)Danielson, K.G., et al. J. Biol. Chem. 270(52):31225-31234(1995)Smolich, B.D., et al. Mol. Biol. Cell 4(12):1267-1275(1993)Clark, C.C., et al. Genomics 18(2):249-260(1993)
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