|Other Names||Integrin beta-6, ITGB6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion|
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Provided below are standard protocols that you may find useful for product applications.
ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands.
Jiang, W.M., et al. Int. Immunol. 4(9):1031-1040(1992)Busk, M., et al. J. Biol. Chem. 267(9):5790-5796(1992)Krissansen, G.W., et al. Immunogenetics 35(1):58-61(1992)Sheppard, D., et al. J. Biol. Chem. 265(20):11502-11507(1990)
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