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ITGB6 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18564 |
|---|---|
| Other Accession | NP_000879.2 |
| Clone Names | 90713106 |
| Gene ID | 3694 |
|---|---|
| Other Names | Integrin beta-6, ITGB6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ITGB6 |
|---|---|
| Function | Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G- D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands.
References
Jiang, W.M., et al. Int. Immunol. 4(9):1031-1040(1992)Busk, M., et al. J. Biol. Chem. 267(9):5790-5796(1992)Krissansen, G.W., et al. Immunogenetics 35(1):58-61(1992)Sheppard, D., et al. J. Biol. Chem. 265(20):11502-11507(1990)
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