|Other Names||Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass membrane protein|
|Tissue Location||Megakaryocytes and platelets.|
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Glycoprotein VI (GP6) is a 58-kD platelet membraneglycoprotein that plays a crucial role in the collagen-inducedactivation and aggregation of platelets. Upon injury to the vesselwall and subsequent damage to the endothelial lining, exposure ofthe subendothelial matrix to blood flow results in deposition ofplatelets. Collagen fibers are the most thrombogenic macromolecularcomponents of the extracellular matrix, with collagen types I, III,and VI being the major forms found in blood vessels. Plateletinteraction with collagen occurs as a 2-step procedure: (1) theinitial adhesion to collagen is followed by (2) an activation stepleading to platelet secretion, recruitment of additional platelets,and aggregation. In physiologic conditions, the resulting plateletplug is the initial hemostatic event limiting blood loss. However,exposure of collagen after rupture of atherosclerotic plaques is amajor stimulus of thrombus formation associated with myocardialinfarction or stroke (Jandrot-Perrus et al., 2000 [PubMed10961879]).
Polgar, J., et al. J. Biol. Chem. 272(21):13576-13583(1997)Asselin, J., et al. Blood 89(4):1235-1242(1997)Huang, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 88(17):7844-7848(1991)Moroi, M., et al. J. Clin. Invest. 84(5):1440-1445(1989)
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