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MESP2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q0VG99
Other Accession NP_001035047.1
Clone Names 91208204
Peptide ID 91208204
Additional Information
Gene ID 145873
Other Names Mesoderm posterior protein 2, Class C basic helix-loop-helix protein 6, bHLHc6, MESP2, BHLHC6, SCDO2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MESP2
Synonyms BHLHC6, SCDO2
Function Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
Research Areas
Citations (0)

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MESP2 is a member of the bHLH family oftranscription factors and plays a key role in defining therostrocaudal patterning of somites via interactions with multipleNotch signaling pathways. This gene is expressed in the anteriorpresomitic mesoderm and is downregulated immediately after theformation of segmented somites. This gene also plays a role in theformation of epithelial somitic mesoderm and cardiac mesoderm.


Cornier, A.S., et al. Am. J. Hum. Genet. 82(6):1334-1341(2008)Morimoto, M., et al. Dev. Biol. 300(2):687-698(2006)Whittock, N.V., et al. Am. J. Hum. Genet. 74(6):1249-1254(2004)McLellan, A.S., et al. Mech. Dev. 119 SUPPL 1, S285-S291 (2002) :Haraguchi, S., et al. Mech. Dev. 108 (1-2), 59-69 (2001) :

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$ 80.00
Cat# BP5705a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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