|Other Names||Sodium/bile acid cotransporter, Cell growth-inhibiting gene 29 protein, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, Sodium/taurocholate cotransporting polypeptide, Solute carrier family 10 member 1, SLC10A1, NTCP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Sodium/bile acid cotransporters are integral membraneglycoproteins that participate in the enterohepatic circulation ofbile acids. Two homologous transporters are involved in thereabsorption of bile acids, one absorbing from the intestinallumen, the bile duct, and the kidney with an apical localization(SLC10A2; MIM 601295), and the other being found in the basolateralmembranes of hepatocytes (SLC10A1).
Ho, R.H., et al. J. Biol. Chem. 279(8):7213-7222(2004)Trauner, M., et al. Physiol. Rev. 83(2):633-671(2003)Hallen, S., et al. Biochemistry 41(23):7253-7266(2002)Shiao, T., et al. Genomics 69(2):203-213(2000)Hagenbuch, B., et al. J. Clin. Invest. 93(3):1326-1331(1994)
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