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SLC10A1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14973 |
|---|---|
| Other Accession | NP_003040.1 |
| Clone Names | 91102234 |
| Gene ID | 6554 |
|---|---|
| Other Names | Sodium/bile acid cotransporter, Cell growth-inhibiting gene 29 protein, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, Sodium/taurocholate cotransporting polypeptide, Solute carrier family 10 member 1, SLC10A1, NTCP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC10A1 |
|---|---|
| Synonyms | NTCP |
| Function | As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352). It is strictly dependent on the extracellular presence of sodium (PubMed:8132774, PubMed:14660639, PubMed:24867799, PubMed:34060352). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in liver (PubMed:11031103, PubMed:12409283). Expressed in placental trophoblasts (PubMed:12409283). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Sodium/bile acid cotransporters are integral membraneglycoproteins that participate in the enterohepatic circulation ofbile acids. Two homologous transporters are involved in thereabsorption of bile acids, one absorbing from the intestinallumen, the bile duct, and the kidney with an apical localization(SLC10A2; MIM 601295), and the other being found in the basolateralmembranes of hepatocytes (SLC10A1).
References
Ho, R.H., et al. J. Biol. Chem. 279(8):7213-7222(2004)Trauner, M., et al. Physiol. Rev. 83(2):633-671(2003)Hallen, S., et al. Biochemistry 41(23):7253-7266(2002)Shiao, T., et al. Genomics 69(2):203-213(2000)Hagenbuch, B., et al. J. Clin. Invest. 93(3):1326-1331(1994)
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