|Other Names||R-spondin-4, Roof plate-specific spondin-4, hRspo4, RSPO4, C20orf182|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.|
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Provided below are standard protocols that you may find useful for product applications.
RSPO4 is a member of the R-spondin family ofproteins that share a common domain organization consisting of asignal peptide, cysteine-rich/furin-like domain, thrombospondindomain and a C-terminal basic region. The encoded protein may beinvolved in activation of Wnt/beta-catenin signaling pathways.Mutations in this gene are associated with anonychia congenital.Alternate splicing results in multiple transcript variants.
Bergmann, C., et al. Am. J. Hum. Genet. 79(6):1105-1109(2006)Blaydon, D.C., et al. Nat. Genet. 38(11):1245-1247(2006)Kim, K.A., et al. Cell Cycle 5(1):23-26(2006)
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