|Other Names||WD repeat-containing protein 11, Bromodomain and WD repeat-containing protein 2, WD repeat-containing protein 15, WDR11, BRWD2, KIAA1351, WDR15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BRWD2, KIAA1351, WDR15|
|Cellular Location||Membrane; Single-pass membrane protein. Cytoplasm Nucleus. Note=Might be shuttling between the nucleus and the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
WDR11 is a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This gene is locatedin the chromosome 10q25-26 region, which is frequently deleted ingliomas and tumors of other tissues, and is disrupted by thet(10;19) translocation rearrangement in glioblastoma cells. Thegene location suggests that it is a candidate gene for the tumorsuppressor locus.
Katoh, M., et al. Int. J. Mol. Med. 11(5):579-583(2003)Katoh, M., et al. Int. J. Oncol. 22(5):1155-1159(2003)Chernova, O.B., et al. Oncogene 20(38):5378-5392(2001)
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