BRWD2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BZH6 |
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Other Accession | NP_060587.8 |
Clone Names | 91109118 |
Gene ID | 55717 |
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Other Names | WD repeat-containing protein 11, Bromodomain and WD repeat-containing protein 2, WD repeat-containing protein 15, WDR11, BRWD2, KIAA1351, WDR15 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | WDR11 |
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Synonyms | BRWD2, KIAA1351, WDR15 |
Function | Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)- derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). |
Cellular Location | Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm Nucleus Cytoplasm, cytoskeleton, cilium axoneme Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Note=Shuttles from the cilium to the nucleus in response to Hh signaling (PubMed:29263200). Might be shuttling between the nucleus and the cytoplasm (PubMed:20887964) |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
WDR11 is a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This gene is locatedin the chromosome 10q25-26 region, which is frequently deleted ingliomas and tumors of other tissues, and is disrupted by thet(10;19) translocation rearrangement in glioblastoma cells. Thegene location suggests that it is a candidate gene for the tumorsuppressor locus.
References
Katoh, M., et al. Int. J. Mol. Med. 11(5):579-583(2003)Katoh, M., et al. Int. J. Oncol. 22(5):1155-1159(2003)Chernova, O.B., et al. Oncogene 20(38):5378-5392(2001)
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