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BRWD2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BZH6
Other Accession NP_060587.8
Clone Names 91109118
Additional Information
Gene ID 55717
Other Names WD repeat-containing protein 11, Bromodomain and WD repeat-containing protein 2, WD repeat-containing protein 15, WDR11, BRWD2, KIAA1351, WDR15
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR11
Synonyms BRWD2, KIAA1351, WDR15
Function Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)- derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865).
Cellular Location Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm Nucleus Cytoplasm, cytoskeleton, cilium axoneme Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Note=Shuttles from the cilium to the nucleus in response to Hh signaling (PubMed:29263200). Might be shuttling between the nucleus and the cytoplasm (PubMed:20887964)
Tissue Location Ubiquitous.
Research Areas
Citations (0)
citation

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Background

WDR11 is a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This gene is locatedin the chromosome 10q25-26 region, which is frequently deleted ingliomas and tumors of other tissues, and is disrupted by thet(10;19) translocation rearrangement in glioblastoma cells. Thegene location suggests that it is a candidate gene for the tumorsuppressor locus.

References

Katoh, M., et al. Int. J. Mol. Med. 11(5):579-583(2003)Katoh, M., et al. Int. J. Oncol. 22(5):1155-1159(2003)Chernova, O.B., et al. Oncogene 20(38):5378-5392(2001)

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$ 277.78
Cat# BP5715c
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