|Other Names||28S ribosomal protein S18c, mitochondrial, MRP-S18-c, Mrps18-c, S18mt-c, 28S ribosomal protein S18-1, mitochondrial, MRP-S18-1, MRPS18C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 28S subunit protein that belongs tothe ribosomal protein S18P family. The encoded protein is one ofthree that has significant sequence similarity to bacterial S18proteins. The primary sequences of the three human mitochondrialS18 proteins are no more closely related to each other than theyare to the prokaryotic S18 proteins. Pseudogenes corresponding tothis gene are found on chromosomes 8p, 12p, 15q, and 22q. [providedby RefSeq].
Zhang, Z., et al. Genomics 81(5):468-480(2003)Cavdar Koc, E., et al. J. Biol. Chem. 276(22):19363-19374(2001)
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