|Other Names||Protein crumbs homolog 2, Crumbs-like protein 2, CRB2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in polarized cells morphogenesis.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart|
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Provided below are standard protocols that you may find useful for product applications.
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. After binding Acetylcholine, the Nicotinic Acetylcholine Receptor (AChR) responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.
Pardossi-Piquard, R., et al. Biochemistry 46(48):13704-13710(2007)Botuyan, M.V., et al. Cell 127(7):1361-1373(2006)van den Hurk, J.A., et al. Mol. Vis. 11, 263-273 (2005) :Humphray, S.J., et al. Nature 429(6990):369-374(2004)Katoh, M., et al. Int. J. Oncol. 24(3):743-749(2004)
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