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FAM105B Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96BN8
Other Accession NP_612357.4
Clone Names 91218078
Peptide ID 91218078
Additional Information
Gene ID 90268
Other Names Ubiquitin thioesterase otulin, Deubiquitinating enzyme otulin, OTU domain-containing deubiquitinase with linear linkage specificity, Ubiquitin thioesterase Gumby, OTULIN, FAM105B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAM105B
Function Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004) :

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$ 80.00
Cat# BP5734c
(40 western blots)
Availability: In Stock
Bulk Size
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