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BHLH3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9C0J9
Other Accession NP_110389
Clone Names 80808005
Peptide ID 80808005
Additional Information
Gene ID 79365
Other Names Class E basic helix-loop-helix protein 41, bHLHe41, Class B basic helix-loop-helix protein 3, bHLHb3, Differentially expressed in chondrocytes protein 2, hDEC2, Enhancer-of-split and hairy-related protein 1, SHARP-1, BHLHE41, BHLHB3, DEC2, SHARP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BHLHE41
Synonyms BHLHB3, DEC2, SHARP1
Function Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}
Tissue Location Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney
Research Areas
Citations (0)

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BHLHE41 may be a transcriptional repressor that represses both basal and activated transcription.


Honma, S., et al. Nature 419(6909):841-844(2002)Garriga-Canut, M., et al. J. Biol. Chem. 276(18):14821-14828(2001)Fujimoto, K., et al. Biochem. Biophys. Res. Commun. 280(1):164-171(2001)Grottke, C., et al. Int. J. Cancer 88(4):535-546(2000)

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$ 80.00
Cat# BP5748a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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