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CHAF1A Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13111 |
|---|---|
| Other Accession | NP_005474 |
| Clone Names | 80924135 |
| Gene ID | 10036 |
|---|---|
| Other Names | Chromatin assembly factor 1 subunit A, CAF-1 subunit A, Chromatin assembly factor I p150 subunit, CAF-I 150 kDa subunit, CAF-I p150, hp150, CHAF1A, CAF, CAF1P150 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CHAF1A (HGNC:1910) |
|---|---|
| Synonyms | CAF, CAF1P150 |
| Function | Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. |
| Cellular Location | Nucleus. Note=DNA replication foci |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Chromatin assembly factor I (CAF1) is a nuclear complexconsisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A)subunits that assembles histone octamers onto replicating DNA invitro (Kaufman et al., 1995 [PubMed 7600578]).
References
Murzina, N., et al. Mol. Cell 4(4):529-540(1999)Shibahara, K., et al. Cell 96(4):575-585(1999)Marheineke, K., et al. J. Biol. Chem. 273(24):15279-15286(1998)Verreault, A., et al. Cell 87(1):95-104(1996)
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