TCF4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P15884 |
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Other Accession | NP_003190.1 |
Clone Names | 90625232 |
Gene ID | 6925 |
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Other Names | Transcription factor 4, TCF-4, Class B basic helix-loop-helix protein 19, bHLHb19, Immunoglobulin transcription factor 2, ITF-2, SL3-3 enhancer factor 2, SEF-2, TCF4, BHLHB19, ITF2, SEF2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TCF4 |
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Synonyms | BHLHB19, ITF2, SEF2 |
Function | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'- CCANNTGG-3'. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22777675} |
Tissue Location | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
TCF4 is transcription factor 4, a basichelix-turn-helix transcription factor. The encoded proteinrecognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - amotif first identified in immunoglobulin enhancers. This gene isexpressed predominantly in pre-B-cells, although it is found inother tissues as well. Defects in this gene are a cause ofPitt-Hopkins syndrome.
References
Rosenfeld, J.A., et al. Genet. Med. 11(11):797-805(2009)Herbst, A., et al. Biochem. Biophys. Res. Commun. 387(4):736-740(2009)Rena, V., et al. Placenta 30(10):876-883(2009)Henthorn, P., et al. Science 247(4941):467-470(1990)
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